What Medications Impact Male Fertility?

If you and your partner are having difficulty conceiving, it's important to consider the medications you may be taking. Certain drugs can have a negative effect on male fertility, impacting sperm production and maturation. It's important to talk to your doctor and a urologist to have your semen tested if you are taking any of these medications. Even if your partner is undergoing chemotherapy, it doesn't mean that your dreams of conception are over.

Doctors usually recommend that men store or freeze sperm beforehand, if possible. As we learn more about the entire process of spermatogenesis and fertilization, and the various factors that determine male fertility, additional endpoints can be added to more precisely define any adverse effects and determine the precise mechanism of action by which a drug exerts these effects. Listed below are several categories of drugs and their effect on the five areas that influence male fertility.


has been found to reduce symptoms of male hypoandrogenism, such as lack of energy, reduced muscle mass, low libido and erectile dysfunction.

Drugs approved by the Food and Drug Administration (FDA) that affect human spermatogenesis, which could have a negative impact on male fertility. After excluding over-the-counter (OTC) drug labels; drugs used only on animals; drugs that were not yet approved by the FDA; and labels on medical foods, medical devices, dietary supplements, cosmetics, bulk ingredients, vaccines, derivatives of plasma, diagnostic kits and similar devices or reagents, a total of 22,724 prescription drug labels for humans were preserved for subsequent data extraction. Because of the large number of possible factors underlying male factor infertility, it is currently impossible to estimate the number of men whose fertility is clinically affected by therapeutic agents. Psychological factors affecting male fertility, which may be altered by treatment with several agents, were also excluded.

Marijuana, or cannabis, has been shown to have a negative impact on male fertility by affecting the hypothalamus, spermatogenesis, sperm function and testicles.


, hormone substitutes and hormone antagonists are well known for their negative impact on male fertility. However, many couples overlook the fact that the male partner's physical condition also affects the chances of conceiving. This is a limitation of the study, since drug-induced male infertility can affect a wide variety of processes and stages, from spermatogenesis to the successful birth of a full-term fetus.

This study also included some symptoms involving pathological changes in the male productive organs, such as Leydig cell tumors, testicles, epididymitis and orchitis, which are likely to affect sperm production and maturation. They can help identify additional medications that affect male fertility that may not have been detected in studies where only a time point or limited time points were examined after starting treatment.


is the trade name for clomiphene and is currently approved by the FDA for female infertility, but doctors can also prescribe clomid to men for unauthorized use. However, since there are many different over-the-counter medications and remedies that haven't been tried, it's best to play it safe.